How does mtor regulate autophagy

You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Autophagy is a process by which components of the cell are degraded to maintain essential activity and viability in response to nutrient limitation.

Extensive genetic studies have shown that the yeast ATG1 kinase has an essential role in autophagy induction. Furthermore, autophagy is promoted by AMP activated protein kinase AMPK , which is a key energy sensor and regulates cellular metabolism to maintain energy homeostasis. Conversely, autophagy is inhibited by the mammalian target of rapamycin mTOR , a central cell-growth regulator that integrates growth factor and nutrient signals.

Here we demonstrate a molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1. This coordinated phosphorylation is important for Ulk1 in autophagy induction.

Our study has revealed a signalling mechanism for Ulk1 regulation and autophagy induction in response to nutrient signalling. He, C. Regulation mechanisms and signaling pathways of autophagy. Wang, R. Autophagy in cellular growth control. FEBS Lett. Hara, T. Cell Biol. Stipanuk, M. Macroautophagy and its role in nutrient homeostasis. Article PubMed Google Scholar. Huang, J. Autophagy and human disease.

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